An AI-designed drug changed six aging clocks

Early human data point to a new model for longevity research.

Sun, Sep 20 · 12:15pm ET Newsletters

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Elysium Health promotes the latest edition of The Abstract, a newsletter discussing recent scientific discoveries on healthy aging. The issue highlights an AI-designed drug that affects six biological aging clocks and explores the potential of GLP-1 drugs, such as semaglutide, to slow aging. The newsletter coincides with Healthy Aging Month, focusing on preserving health and function with age.

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Elysium Health www.elysiumhealth.com

Elysium creates clinically proven longevity supplements developed with world-leading scientists. Target cellular health with research-backed healthy aging supplements.

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Thanks for reading The Abstract. This month’s edition is 1,176 words, about a 4-minute read.

Is there a topic that you’d like to see more of in The Abstract? Drop us a line at [email protected]. Want to get The Abstract in your inbox? Sign up here.

The Abstract

September is Healthy Aging Month—a fitting time to ask not only how long we can live, but how science might help us preserve health and function along the way. In this edition of The Abstract: an AI-designed drug moves six biological aging clocks, semaglutide reveals effects in older mice that calorie restriction alone cannot explain, three minutes of sprinting transforms the molecular landscape of the blood, “intrinsic capacity” emerges as a potential measure of healthspan, and a large study connects the timing of our first meal with longevity.

Could GLP-1 drugs slow aging?

Semaglutide, a GLP-1 receptor agonist, suppresses appetite, and eating fewer calories can extend lifespan in mice. So when researchers gave the drug to healthy 20-month-old female mice—roughly equivalent to 60-year-old humans—they wanted to know whether it could do anything more. Semaglutide-treated mice ate 24% less and lived 12% longer, reaching a median lifespan of 834 days versus 742 days for untreated controls. Mice fed the same reduced number of calories lived about as long, making it unclear whether semaglutide extended lifespan through effects beyond appetite reduction. But the semaglutide group performed better on spatial memory and several other measures of function—suggesting that some healthspan benefits may not be explained by eating less. Currently there is no evidence suggesting the same results could be extrapolated to humans.

The Expert’s Take:

“The paper from Danica Chen and Will Bohr shows that semaglutide (Wegovy) extends the life span of mice when given late in life (20 months). By a thorough set of physiological and molecular analyses, the authors convincingly show a strong overlap of the effects of the GLP-1 activator and the diet of calorie restriction. These include increased physical activity and dexterity, mitigation of aging phenotypes of stem cells, increases in NAD+ and expression of sirtuin genes, decreased IGF-signaling and improved insulin sensitivity, just to name a few of the many tests performed. Are there any differences between calorie restriction and semaglutide treatment? Mice on calorie restriction eat their food instantaneously when it is provided, while the drug-treated mice eat it at a leisurely pace. The former crave food, while the latter tolerate it. In humans, volunteers for calorie restriction trials are hard to find, while doctors are bombarded by frantic petitioners for semaglutide prescriptions.”

Button Leonard Guarente, Ph.D.

Novartis Professor of Biology at MIT and Elysium co-founder and chief scientist

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THIS MONTH

What We’re Reading

These are third-party articles about science that we find interesting but have no relationship to Elysium or any of our products. Elysium’s products are not intended to screen, diagnose, treat, cure, or prevent any disease.

How three minutes of sprinting changes your blood

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