The Marker You're Missing: Lp(a)
The genetic heart risk marker everyone should test once
Levels <[email protected]>
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Levels promotes testing for Lp(a), a genetic risk factor for heart disease that is barely affected by diet, exercise, or medication. The company highlights the importance of knowing one's Lp(a) level to inform heart health management. Levels offers a one-time heart test to determine this key marker.
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The Marker You're Missing: Homocysteine
The marker that changes how you think about your other heart markers
Lp(a) is one of the strongest known genetic risk factors for heart disease, and it barely responds to diet, exercise, or most current medications. That's exactly why it's worth testing. Knowing your number can impact how aggressively you and your doctor manage everything else that is in your control, like LDL, blood pressure, and smoking. A high Lp(a) is essentially a signal to tighten the reins on the levers you can move. Since levels stay stable for life, this is a test you take once, not something to add to a rotating panel.
Button The one-time heart test →
The Basics
What it is
Lp(a) is an LDL-like particle, but unlike LDL or ApoB, which respond meaningfully to diet and exercise, your Lp(a) level is set almost entirely by genetics.
Why it matters
It's "stickier" than regular LDL, promotes clotting, and triggers inflammation in vessel walls, three separate mechanisms a standard cholesterol test won't show you. Genetic studies that isolate Lp(a)-raising variants find a corresponding jump in heart attack risk, so this is one of the few markers where the science has moved past correlation to established causality. Whether lowering it with medication actually reduces that risk is still being tested in ongoing trials.
Healthy range
Below 75 nmol/L. Roughly 20 to 30 percent of people carry a genetically elevated level.
What moves it
Very little. Diet and exercise typically shift Lp(a) by only 10 to 15 percent at most. It can tick up somewhat with hypothyroidism, chronic kidney disease, or after menopause.
When to test
Worth doing once in adulthood, especially with a family history of early heart disease or high cholesterol that doesn't add up. Levels stay stable for life, so there's rarely a reason to retest once you know your number.
Button Read the full guide →
Related Video: Cholesterol Explained
Looking to understand more about your metabolic health?
Explore our health news and advice site, Metabolic Insights
228 Park Ave South, PMB 63877, New York, NY 10003
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- The Marker You're Missing: Lp(a)
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